Examples:

• What's up with the boss this morning, Mr. Gloatbridge?
• What's up with the bad juju in this car?
• That's what I want to see, baby. What's up, man?
• What's up with the red mark on his treasure trail?
• What's up with the visit after all this time?
• What's up people that are not wearing their Speedos?
• Well, if it isn't Beauty and the Beast. What's up?
• What's up with that niece of yours, Miss Bruce Lee?
• What's up is that you owe me an apology.
• What's up with this secret plan of yours tonight, huh?